lec17_18_19cellcycle_apoptosiss

lec17_18_19cellcycle_apoptosiss - Figure 17-69 Molecular...

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Figure 17-69 Molecular Biology of the Cell (© Garland Science 2008)
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Factors Regulating Cell Growth Class Action Mechanism Mitogen Stimulate cell division Generally act by relieving negative controls preventing progress through cell cycle Growth Factor Stimulate cell growth (increase in cell mass) Promote synthesis of proteins and other macromolecules Survival Factor Promote cell survival Suppress apoptosis
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Outline History Timing of event / how to study Regulation of Cell Cycle (general) Cyclin Proteolysis Phosphorylation Inhibition More on Specific Cdk G1 S M
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Model Organisms Used to Study the  Cell Cycle Yeast Frog embryos Cultured Mammalian Cells
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Eucaryotic Cell Division Why is interphase so long?
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Cell Fusion Experiments Provide  Evidence For Rereplication Block
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Behavior of Temperature-Senstitive  Cell Cycle Mutant
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Phases of the Cell Cycle
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Control of  Cell Cycle The 2001 Nobel Prize in  Physiology or Medicine
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Checkpoints  in Cell Cycle
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Two Key Components of  Cell-Cycle Control System kinases Both required Cyclin-dependent kinases (Ddk) Family of related kinases Activity rises and falls during cell  cycle Controlled by association with cyclins Other proteins affect cdk activity as  well
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Simplified View Of  Cell-Cycle Control  System Association with cyclin is 
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This note was uploaded on 04/20/2010 for the course BIOL 4064 taught by Professor Dr.reyna during the Spring '09 term at Ouachita Baptist.

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lec17_18_19cellcycle_apoptosiss - Figure 17-69 Molecular...

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