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Lab Presentation - Regulation of Rheumatoid Arthritis by...

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Unformatted text preview: Regulation of Rheumatoid Arthritis by Inhibition of the NF-κB Pathway Ouachita Baptist University Jason Hill Colt Swayze What is the NF-κB Pathway? Ø Nuclear Factor kappa-light-chain-enhancer of activated B cells Ø Controls the transcription of DNA Ø Produces the inflammatory proteins responsible for immune response to antigens Ø Proteins activate B cells, which attack antigen- bearing substance Ø Important pathway in finding treatments for inflammatory diseases such as Rheumatoid Arthritis The NF-κB Pathway Key Steps in the NF-κB Pathway: Potential Inhibitory Methods 1. Binding of Activator to receptor 2. Activation of IκK 3. Phosphorylation of IκB complex 4. Ubiquitination of IκB complex 5. Proteasome Degradation of IκB complex 6. Transport of NF- κB across nuclear membrane 7. Transcription 8. Export of Inflammatory protein How does the NF-κB Pathway Pertain to Cell Biology?...
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This note was uploaded on 04/20/2010 for the course BIOL 4064 taught by Professor Dr.reyna during the Spring '09 term at Ouachita Baptist.

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Lab Presentation - Regulation of Rheumatoid Arthritis by...

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