NF-kB Presentation

NF-kB Presentation - NF-kB1.Wikipedia information1.Overview1.NF-κB(nuclear factor kappa-light-chain-enhancer of activated B cells is a protein

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Unformatted text preview: NF-kB1.Wikipedia information1.Overview1.NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls the transcription of DNA. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.[1][2][3][4][5] NF-κB plays a key role in regulating the immune response to infection. Conversely, incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.2.Discovery1.NF-κB was first discovered in the lab of Nobel Prize laureate David Baltimore via its interaction with an 11-base pair sequence in the immunoglobulin light-chain enhancer in B cells.[7]3.Structure1.All proteins of the NF-κB family share a Rel homology domain in their N-terminus. A subfamily of NF-κB proteins, including RelA, RelB, and c-Rel, have a transactivation domain in their C-termini. In contrast, the NF-κB1 and NF-κB2 proteins are synthesized as large precursors, p105, and p100, which undergo processing to generate the mature NF-κB subunits, p50 and p52, respectively. The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway and involves selective degradation of their C-terminal region containing ankyrin repeats. Whereas the generation of p52 from p100 is a tightly-regulated process, p50 is produced from constitutive processing of p105. [8][9]4.Members1.NF-κB family members share structural homologywith the retroviral oncoproteinv-Rel, resulting in their classification as NF-κB/Rel proteins.[1]2.There are five proteins in the mammalian NF-κB family:[10]ClassProteinAliasesGeneClass INF-κB1p105 → p50NFKB1NF-κB2p100 → p52NFKB2Class IIRelAp65RELARelBRELBc-RelREL3. Below are the five human NF-κB family members:NFKB1Top view of the crystallographic structure (PDB1SVC) of a homodimer of the NFKB1protein (green and magenta) bound to DNA (brown).IdentifiersSymbolNFKB1Entrez4790HUGO7794OMIM164011RefSeqNM_003998UniProtP19838Other dataLocusChr. 4q24RELASide view of the crystallographic structure (PDB2RAM) of a homodimer of the RELA protein (green and magenta) bound to DNA (brown).IdentifiersSymbolRELAEntrez5970HUGO9955OMIM164014RefSeqNM_021975UniProtQ04206Other dataLocusChr. 11q13NFKB2IdentifiersSymbolNFKB2Entrez4791HUGO7795OMIM164012RefSeqNM_002502UniProtQ00653Other dataLocusChr. 10q24RELBIdentifiersSymbolRELBEntrez5971HUGO9956OMIM604758RefSeqNM_006509UniProtQ01201Other dataLocusChr. 19q13.2-19q13RELIdentifiersSymbolRELEntrez5966HUGO9954OMIM164910RefSeqNM_002908UniProtQ04864Other dataLocusChr. 2p13-p124. In addition, there are NF-κB proteins in invertebrates, such as the fruit flyDrosophila, sea urchins, sea anemones, and sponges....
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This note was uploaded on 04/20/2010 for the course BIOL 4064 taught by Professor Dr.reyna during the Spring '09 term at Ouachita Baptist.

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NF-kB Presentation - NF-kB1.Wikipedia information1.Overview1.NF-κB(nuclear factor kappa-light-chain-enhancer of activated B cells is a protein

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