Lecture 6 - ioE10: Lecture 4 Professor Irina Conboy BioE10:...

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Unformatted text preview: ioE10: Lecture 4 Professor Irina Conboy BioE10: Lecture 4 Professor Irina Conboy Cellular bioengineering Review of cellular anatomy Objectives: Understand how structure and function are interconnected in eukaryotic cells and thus, understand the approaches and challenges of cellular engineering Biological fundamentals: Nucleus, ER, Golgi apparatus Protein folding, transport and sorting; Nuclear transport; nuclear pore Cytoplasm, plasma membrane; Cytoskeleton; Progeria; Lamins, LaminA Figure 7-6a Generalized animal cell Nuclear envelope Nucleolus Nucleus Centrioles Chromosomes Rough endoplasmic reticulum Ribosomes Peroxisome Smooth endoplasmic reticulum Golgi apparatus Lysosome Mitochondrion Cytoskeletal element Plasma membrane Figure 7-22 hromosomes Chromosomes Nuclear lamina Inner membrane Nucleus Nuclear envelope Outer membrane Rough ER Ribosome Cytoplasm Figure 7-23 Outer surface of nuclear envelope Nuclear pores Figure 7-24a Cross-sectional view of nuclear pore DNA in nucleus Inner membrane Outer membrane Cytoplasm Nuclear matrix Nuclear envelope Cytoplasm Nuclear pore complex Q: Is DNA of prokaryotic or eukaryotic cells susceptible to damage (by UV or O 2- )and why? Figure 7-24b Molecules move into and out of the nucleus through the nuclear pore uclear matrix mRNAs to cytoplasm Nuclear matrix Nuclear nvelope Cytoplasm envelope Nuclear ore po e complex Proteins needed in nucleus Q: What is one major class of proteins that is definitely needed in nucleus? Progeria: molecular understanding of the genetic defect...
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Lecture 6 - ioE10: Lecture 4 Professor Irina Conboy BioE10:...

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