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QB_D - BIO320 Question bank D lectures 21-23 Eukaryotic...

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BIO320 – Question bank D; lectures 21-23. Eukaryotic chromosomes, chromatin & gene expression 1. To study how retrotransposons are copied to new sites in the genome, an intron was placed experimentally into a cloned yeast retrotransposon, Ty1, and the modified Ty1 DNA was inserted into a yeast chromosome. Further transpositions of this Ty1 element into other chromosomal sites were found to be missing the intron. This experiment showed that: A. Yeast cells excise introns from their chromosomal DNA. B. Ty1 transposition involves an RNA intermediate that can undergo splicing. C. The Ty1 transposase has spliceosome activity. D. Yeast cells lack a splicing mechanism. E. Ty1 transposition involves a DNA intermediate that can undergo splicing. 2. A non-autonomous DNA transposon is no longer independently mobile because it has... 3. These are various substructures in the arrangement of eukaryotic DNA. Number them in order of increasing size (i.e. diameter or thickness): DNA helix, chromatid, 30nm fiber, nucleosome, chromosome, histone octamer. 4. The total length of the DNA in a diploid set of human chromosomes is about 2 meters, yet this DNA must fit into a nucleus that is less than 10 mM (10 -5 m) in diameter. This is accomplished by: A. Removal by splicing of the introns and other non-coding regions that make up the bulk of the DNA. B. Several levels of coiling and looping, beginning with the coiling of DNA into nucleosomes. C. Cutting the DNA into short lengths by DNAse I and other endonucleases. D. Hyperacetylation of histone proteins. E. Inactivation and condensation of one homolog from each chromosome pair. 5. Which of the following statements about the histones and nucleosomes in eukaryotic chromatin is FALSE:
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