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NUT116B_Y10_Cancer

NUT116B_Y10_Cancer - Cancer Lectures#1 2 and 3 on and...

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Cancer Lectures #1, 2, and 3 on 02/03/10, 02/05/10 and 02/08/10 respectively
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NUMBERS OF DEATHS FOR THE 10 LEADING CAUSES OF DEATH UNITED STATES, 1980 AND 1982 1980 1982 1. Diseases of the heart 763,060 759,050 2. Malignant neoplasms, including 414,320 435,550 neoplasms of lymphatic and hematopoietic tissues 3. Cerebrovascular diseases 170,420 159,630 4. Accidents and adverse effects 106,550 96,680 Motor vehicle accidents 54,200 46,630 Other accidents & adverse effects 52,350 49,050 5. Chronic obstructive pulmonary 55,810 59,980 diseases and allied conditions 6. Pneumonia and influenza 52,720 50,460 7. Diabetes mellitus 34,230 33,220 8. Suicide 28,100 27,860 9. Chronic liver disease 29,520 27,250 10. Atherosclerosis 28,750 26,550
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FIVE-YEAR RELATIVE SURVIVAL RATES 1 FOR SELECTED SITES FOR WHITE CANCER PATIENTS 43 49 49 53 0 20 40 60 80 100 Colon Percent 63 68 74 75 0 20 40 60 80 100 Breast (female) Percent 73 81 89 86 0 20 40 60 80 100 Uterine Corpus Percent 53 61 73 74 0 20 40 60 80 100 Bladder Percent 31 41 45 48 0 20 40 60 80 100 Non-Hodgkin's Lymphoma Percent 37 46 50 50 0 20 40 60 80 100 Kidney Percent 40 67 67 74 0 20 40 60 80 100 Hodgkin's Disease Percent 63 72 76 87 0 20 40 60 80 100 Testicular Percent 60 68 76 80 0 20 40 60 80 100 Melanoma of the Skin Percent 14 22 33 33 0 20 40 60 80 100 Leukemia Percent 50 63 65 71 0 20 40 60 80 100 Prostate Percent 1960-1963 1970-1973 1973-1975 1976-1981
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TRENDS IN U.S. CANCER MORTALITY, 1973-92 -66.2 -56.9 -43.1 -34.5 -25.9 -22.9 -21.3 -21.1 -17.4 -6.2 -4.7 -3.3 -1.3 0.6 15.3 16.5 16.6 18 23.2 29.2 31.1 34.1 136.5 -3.4 35.9 6.3 -200 -150 -100 -50 0 50 100 150 200 CHANGE IN DEATH RATE (PERCENT) PANCREAS LARYNX LEUKEMIAS OVARY COLON: RECTUM ORAL CAVITY: PHARYNX THYROID URINARY BLADDER UTERUS (EXCLUDING CERVIX) STOMACH UTERINE CERVIX HODGKIN’S DISEASE TESTIS LUNG (FEMALES) NON-HODGKIN’S LYMPHOMA MELANOMAS OF SKIN MULTIPLE MYELOMA LIVER: BILE DUCT PROSTATE KIDNEY: RENAL PELVIS ESOPHAGUS LUNG (MALES) BRAIN: NERVOUS SYSTEM BREAST (FEMALES) ALL EXCEPT LUNG ALL CANCERS SOURCE: SEER Statistics Review, 1973-1992. NIH Publication No. 96-2189 National Cancer Institute. 1995.
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Lung Metastases Liver Metastases Visible Tumor Initiating Agent THE NATURAL HISTORY OF NEOPLASIA Increasing Aneuploidy Euploid Cell Population Progression Promotion
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Normal cells Cancer cells
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Normal cells Cancer cells RBC Rosettes
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Schematic of cell differentiation
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Site of action of folate in erythropoiesis ERYTHROPOIESIS Reticulocyte Red blood cell JN 1988,118:1089 Blood 1992,79:2280 Stem cell BFU-E CFU-E Folate Proerythroblast Basophilic erythroblast Polychromatic erythroblast Pyknotic erythroblast Eject nucleus
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Table 20. Proportions of Cancer Deaths Attributed to Various Different Factors Percent of all cancer deaths Factor or class of factors Best Range of estimate acceptable estimate Text section No. 5.1 Tobacco 30 25-40 5.2 Alcohol 3 2-4 5.3 Diet 35 10-70 5.4 Food additives <1 -5 a -2 5.5 Reproductive b and sexual behaviour 7 1-13 5.6 Occupation 4 2-8 5.7 Pollution 2 <1-5 5.8 Industrial products <1 <1-2 5.9 Medicines and medical procedures 1 0.5-3 5.10 Geophysical factors c 3 2-4 5.11 Infection 10? 1-? 5.12 Unknown ? ?
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10.1 21.7 45 14.2 40.7 67.3 0 10 20 30 40 50 60 70 80 1962-64 1972-73 JAPAN 1960-64 1968-72 HAWAII 1960-64 1968-72 HAWAII JAPANESE Age-adjusted breast cancer incidence rates in native Japanese, Hawaiian Japanese, and white Hawaiians.
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