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NUT116B+Y05+Anemia020110

NUT116B+Y05+Anemia020110 - ANEMIAS Lecture 3 Nutrition 116...

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Lecture 3 Nutrition 116 B ANEMIAS
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ANEMIA RESULTS FROM: 1. Reduced production of red cells 2. Reduced synthesis of hemoglobin by red cell precursors 3. Increased destruction of red cells 4. Loss of red cells from circulation 5. Combination of above causes
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ERYTHROPOESIS Folate & Erythropoeitin
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1 The cutoff values were estimated using the method of Dallman et al. (1984) 2 Because of the small sample size, the value obtained for subjects aged 3-4 years was also used for subjects aged 1-2 years Hemoglobin Cutoff Values Age (yr) Males & Females Males Females HEMOGLOBIN (g/100 mL) 1-2 10.9 2 - - 3-4 10.9 - - 5-10 11.2 - - 11-14 - 12.0 11.8 15-19 - 13.1 11.7 20-44 - 13.4 11.9 45-64 - 13.2 11.8 65-74 - 12.6 11.9
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Synthesis of Hemoglobin PURINE BASES PYRIMIDINE BASES NUCLEIC ACIDS AMINO ACIDS NUCLEUS CYTOPLASM RIBOSOME GLYCINE SUCCINATE HEME DNA Fe HbA HbF HbA 2 (97%) (<1%) (2%) (Via messenger RNA) β α δ β γ α δ γ α 2 β 2 α 2 γ 2 α 2 δ 2
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ANEMIAS EMBRYONIC CHAIN EMBRYONIC CHAIN γ CHAIN (FETAL) α CHAIN β CHAIN (ADULT) δ CHAIN (ADULT) POINT OF INSTABILITY
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PERIPHERAL TISSUE HEMOGLOBIN
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  • Winter '10
  • AndrewClifford,PhD
  • red cells, Jejunum Ileum Colon, Hemoglobin Cutoff Values, HEMOGLOBIN MYOGLOBIN CYTOCHROMES, γ CHAIN

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