Lecture-11-Cell-Comm_38751

Lecture-11-Cell-Comm_38751 - CellCommunication

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Cell Communication Cell to cell communication is essential for coordinating and controlling cellular activities: in response to extracellular changes response to environmental changes in the organism’s surrounding in response to environmental changes in the organism s surrounding for execution of various functions: development, digestion, sensory functions, respiration, etc. Much of cellular communication occurs via a signal transduction pathway and is based on: Signal (usually a olecule) Cell Cell Activate metabolic molecule) Usually originating from another cell or Signal “ eceivers” Signal reception converts (transduces) pathways from the physical environment receivers on, or in, the cell signal to intracellular form that intiates cellular activity
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Cell Communication vs. Distance cal signaling: Local signaling: Cell:Cell contact: gap junctions, plasmodesmata cell:cell recognition via receptor & membrane glycoproteins Paracrine signaling Signaling cell secretes molecular messenger that travels a short distance, influencing cells in the vicinity ± Local regulators – Synaptic signaling cretion f – Secretion of neurotransmitter by excited nerve cell t ti l t that stimulates a nearby target cell
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Long Distance Communication ng Distance signaling Long Distance signaling: Endocrine cells (animals) secrete hormones to the circulatory system avel to into the circulatory system Æ travel to target cells in various parts of the body. Signaling via transmission of nerve impulses to different parts of the body Cellular response to a signal Sutherland (1971): found that the plasma membrane of target cells is involved in transmitting the epinephrine hormone signal. hre ages in the signal transduction response: Three stages in the signal transduction response: Reception : cell surface or internal receptor binds signal molecule Transduction : binding changes receptor protein initiating cellular response by activating relay molecules. Response : cellular activity Æ enzyme activation, gene activation
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Reception of Signal Binding by signal molecule (or ligand) induces shape change in the receptor protein, causing either… –A c t i v a t i o n o f the protein, enabling it to interact w/cellular molecules… –o r cause aggregation of two or more receptor molecules, that leads ft h ll t to further molecular events.
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This note was uploaded on 04/23/2010 for the course BIOL 1361 taught by Professor Knapp during the Spring '05 term at University of Houston.

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Lecture-11-Cell-Comm_38751 - CellCommunication

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