1362-SU09-Lecture-2-_39836

1362-SU09-Lecture-2-_39836 - ?Theypossessa ,inherited...

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The Big Picture View of Inheritance •T h e survival of a species ultimately relies on the survival & reproductive success of its members. •W h a t characterizes such successful individuals? They possess a b l bi ti f ti t h i td i ti & favorable combination of traits, inherited from prior generations & molded by nature, that allows them to be well adapted to their environment. They are survivors. Some factors of success… avoid predators p Genetic variation in a population is “f l” f lt i breeding success the “fuel” for evolution. Is the variation here only what you can visibly see?
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A mysterious medical malady seen in 1904 • Microscopic observation of blood sample from patient complaining of weakness, dizziness, shortness of breath, & pain: atient’s red compare to… normal RBC’s patient s red blood cells •P a t i e n t s father & 2 sisters died from ailments damaging their lungs, kidneys. Did they have sickle shaped RBC’s? A connection between normal cells and the illness? Why are cells sickle shaped? abnormal cells and the illness? Why are cells sickle shaped? •S y m p t o m s characteristic of genetic disorder term sickle cell anemia: occurs when a person receives two copies of a gene that codes for an tered hemoglobin protein subunit altered hemoglobin protein subunit. Hemoglobin: O 2 transporting protein in RBC’s Sickle cells cause multiple complications in affected persons. •T h e connection here: chromosomes Æ DNA Æ gene Æ protein h e study of such heritable traits began much earlier…
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Gregor Mendel examined heritable characters of the garden pea such as flower color & seed form. udied variations among characters called aits – Studied variations among characters, called traits . –Ob s e r v ed that traits sometimes disappeared from 1 generation to the next, but then reappeared in later generations. Refuted “Blending Theory of Inheritance” –Fo rmu l a t ed “Particulate Theory of Inheritance”; traits governed by heritable “particles” or “factors. • Mendel’s Experiment’s: cross pollination of plants possessing character variations; describe & count phenotypes obtained among ffspring offspring. stigma extension f l Offspring = seeds anthers of carpel ow & examine contain pollen (male carpel contain female gametes (eggs) grow & examine traits in adult *Self fertilization: fertilize plant with its own pollen Cross = pollen to stigma gametes)
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•B e gin by crossing plants known to be P Generation Mendel’s Monohybrid Cross true breeding for both variations of a trait (e.g., purple v. white flowers) esignated parental (P) generation Designated parental (P) generation Plants developed from seeds of this oss: generation =filial); ll urple cross: F1 generation (F filial); all purple flowered (white trait disappeared?) *No blending of white & purple color F1 all purple flowers self fertilize: (F1 x F1) Self fertilize F1’s; offspring are the F2 generation (white flowers reappear!; 5% purple flowered 5 white F2
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This note was uploaded on 04/23/2010 for the course BIOL 1361 taught by Professor Knapp during the Spring '05 term at University of Houston.

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1362-SU09-Lecture-2-_39836 - ?Theypossessa ,inherited...

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