Mammalian Test 03

# Mammalian Test 03 - 1 Define renal clearance Hypothetical...

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1. Define renal clearance. Hypothetical plasma volume containing the amount of any substance excreted in the urine per minute. 2. Calculate the renal clearance of substance X given the following: Tmax of substance X = 300 mg/min GFR = 200 ml/min Plasma concentration of X = 400 mg/100 ml Urine volume = 80 ml/20 min Renal fraction = 25% Hematocrit = 50 Urine concentration of X = 50 mg/10 ml Blood pressure = 130/85 3. Calculate the GFR given the following: Renal blood flow = 2,000 ml/min Urine volume = 10 ml/min Filtration fraction = 20% Tmax of glucose = 300 mg/min Creatinine clearance = 225 Glucose clearance = 0 Cardiac output = 6,000 ml/min 4. Calculate the tubular load of substance X given the following: Plasma concentration of X = 2 mg/ml Urine volume = 6 ml/min Tmax of X = 200 mg/ml Clearance of PAH = 800 Hematocrit = 50 Amount of X excreted = 100 mg/min Renal fraction = 30% 5. Calculate the GFR given the following: Renal plasma threshold of X = 3 mg/ml Renal clearance of PAH = 800 Hematocrit = 50 Urine volume = 3 ml/min Tmax of X = 240 mg/min Cardiac output = 5000 ml/min Renal fraction = 20% 6. Calculate the amount of inulin excreted per minute given the following: Cardiac output = 5,000 ml/min GFR = 150 ml/min Plasma concentration of inulin = 2 mg/ml Creatinine clearance = 900 Renal fraction = 20% HCT = 50

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Suppose line X represents the amount of glucose that is filtered Draw a similar line representing this line for the amount of uric acid filtered and label it Y Draw a third line representing the amount of uric acid filtered under the influence of Probenecid and label it Z. ANSWER FOLLOWING QUESTIONS 1 THROUGH 56 ON SCAN SHEET 1. Would cause an increase in thirst A. Hypertonicity in area of the hypothalamic osmoreceptors B. High pressure in left atrium C. Angiotensin II D. All of these E. A & C 2. Function(s) of the kidney A. Secrete H + D. All of these B. Regulate blood pressure E. Two of the above are correct C. Produce hormones 3. Which is (are) a correct sequence that a drop of filtrate might take. Only sequence is important. A. Proximal convoluted tubule, calyx, collecting duct, bladder B. Thin segment, thick segment, renal pelvis, ureter C. Bowman's capsule, collecting duct, urethra, bladder D. None of these E. Two of the above are correct 4. Found in the medulla A. Renal pyramids D. All of these B. Ureters E. Two of the above are correct C. Thin segment 5. Which is a correct sequence that a RBC would take in going through the kidney. Only the sequence is important. A. Renal artery, Efferent arteriole, Afferent arteriole, Renal vein B. Glomerulus, Bowman's Capsule, Peritubular capillaries, Renal vein C. Arcuate artery, Interlobular artery, Peritubular capillary, Renal vein D. None of these E. Two of the above are correct 6. Podocytes are: A. Part of the glomerulus D. All of these B. Octopus shaped E. Two of the above C. May be effected by aldosterone 7. Which of the following symptoms is associated with acidosis?
A. Extreme nervousness

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## This note was uploaded on 04/23/2010 for the course BIOL 5600 taught by Professor Wit during the Spring '06 term at Auburn University.

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Mammalian Test 03 - 1 Define renal clearance Hypothetical...

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