IBS602-Wang Lecture

IBS602-Wang Lecture - IBS 602 Lecture Translesion DNA...

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IBS 602 Lecture Translesion DNA Synthesis Dr. Zhigang Wang Graduate Center for Toxicology
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CELLULAR RESPONSES TO DNA DAMAGE I. DNA Repair 1. Nucleotide Excision Repair 2. Base Excision Repair 3. Mismatch Repair 4. Recombinational repair 5. Direct Enzymatic Reversal of the Damage II. Cell Cycle Checkpoint Response III. Apoptosis IV. Damage Tolerance 1. Translesion DNA Synthesis (Error-free or Error-prone) 2. Template Switching (Error-free)
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Some damage can persist in the genome during replication when: 1. Cells sustain significant DNA damage; 2. A particular damage is poorly repaired; 3. Some genomic regions are inefficiently repaired; 4. DNA damage occurs at the S phase of the cell cycle. Cellular Defense Systems against DNA Damage Do Not Function Perfectly
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DNA Lesions Frequently Block Replication damage
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Translesion synthesis (TLS): A cellular mechanism (DNA damage tolerance) in response to DNA lesions during replication.
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Translesion Synthesis 1. Error-free TLS Predominantly incorporates the correct nucleotide
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This note was uploaded on 04/24/2010 for the course IBS 602 taught by Professor Staff during the Spring '08 term at Kentucky.

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IBS602-Wang Lecture - IBS 602 Lecture Translesion DNA...

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