Dr Mellon - Supplementary Material

Dr Mellon - Supplementary Material - Supplementary Material...

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Supplementary Material to Lecture 1 This information is Required Know the salient contributions to the solution of the double helix Be able to recognize the structures of nucleotides and base pairs Be able to describe/draw the basic structure of DNA and RNA Be able to describe the flow of genetic information
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Contributions to the Elucidation of the DNA Double Helix Previous genetic and biochemical studies had provided substantial evidence that most genetic molecules are made of DNA Avery, MacLeod, & McCarty (1944); Hershey and Chase (1952) Relative ratios of the 4 bases in DNA are not random. A=T and G=C purines = pyrimidines Chargaff (1949) Chargaff’s rules Elegant theory of diffraction of helical molecules was developed High quality X-ray diffraction photographs were taken Complementary double helix proposed Watson & Crick (1953)
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Nucleic acids differ in their pentose sugar Figure 1.01: The two sugars present in nucleic acids.
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Dr Mellon - Supplementary Material - Supplementary Material...

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