1. Nucleosides, nucleotides, and polynucleotideLecture 5: DNA and RNA Structures2. DNA double helix3. Other structural properties of DNA DNA Denature and renatureDNA sequence and sequence homologyDNA supercoil5’-3’ polarityAnti-parallel nature of the double strandComplementary nature of the double strand4. RNA structuretRNA, rRNA, mRNA, hnRNA, miRNA, etcNucleotide StructureNucleotide StructurezThe sugar in all The sugar in all nucleotides is a 5 nucleotides is a 5 carbon (pentose) carbon (pentose) sugar.sugar.zDNA and RNA each DNA and RNA each contain 4 kinds of contain 4 kinds of bases.bases.zWithout a phosphate Without a phosphate this would be a this would be a nucleonucleosideside.
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Ribose and Ribose and DeoxyriboseDeoxyribosezThe sugar in RNA is ribose.The sugar in RNA is ribose.zThe sugar in DNA is The sugar in DNA is deoxyribosedeoxyribose.zIn both DNA and RNA the base is attached to In both DNA and RNA the base is attached to the 1the 1’carbon.carbon.Fig. 2-14The Bases in The Bases in DNA and RNADNA and RNAzDNA contains the four DNA contains the four bases A,G,C & TzRNA contains the four RNA contains the four bases A,G,C & UzIn nucleotides the Nitrogen atom shown Nitrogen atom shown in in REDREDis bonded to is bonded to the 1the 1’carbon of ribose carbon of ribose (in RNA) and to the 1(in RNA) and to the 1’carbon of deoxyribose(in DNA)(in DNA)PURINESPYRIMIDINESAdenine (A)Uracil (U)Guanine (G)Thymine (T)Cytosine (C)