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LS5DNARNAstructure - Lecture 5 DNA and RNA Structures 1...

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1. Nucleosides, nucleotides, and polynucleotide Lecture 5: DNA and RNA Structures 2. DNA double helix 3. Other structural properties of DNA DNA Denature and renature DNA sequence and sequence homology DNA supercoil 5’-3’ polarity Anti-parallel nature of the double strand Complementary nature of the double strand 4. RNA structure tRNA, rRNA, mRNA, hnRNA, miRNA, etc Nucleotide Structure Nucleotide Structure z The sugar in all The sugar in all nucleotides is a 5 nucleotides is a 5 carbon (pentose) carbon (pentose) sugar. sugar. z DNA and RNA each DNA and RNA each contain 4 kinds of contain 4 kinds of bases. bases. z Without a phosphate Without a phosphate this would be a this would be a nucleo nucleo side side .
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Ribose and Ribose and Deoxyribose Deoxyribose z The sugar in RNA is ribose. The sugar in RNA is ribose. z The sugar in DNA is The sugar in DNA is deoxyribose deoxyribose. z In both DNA and RNA the base is attached to In both DNA and RNA the base is attached to the 1 the 1’ carbon. carbon. Fig. 2-14 The Bases in The Bases in DNA and RNA DNA and RNA z DNA contains the four DNA contains the four bases A,G,C & T z RNA contains the four RNA contains the four bases A,G,C & U z In nucleotides the Nitrogen atom shown Nitrogen atom shown in in RED RED is bonded to is bonded to the 1 the 1’ carbon of ribose carbon of ribose (in RNA) and to the 1 (in RNA) and to the 1’ carbon of deoxyribose (in DNA) (in DNA) PURINES PYRIMIDINES Adenine (A) Uracil (U) Guanine (G) Thymine (T) Cytosine (C)
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