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150-JP4(L3) - BISC 150 Petruska Lecture 4 Human(and Sexual...

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BISC 150 Petruska Lecture 4 Human (and Sexual) Development 150-JP4(L3).ppt (Review 150-JP3(L10).ppt slides 12-19) References: Lewis, Human Genetics (8th Ed. 2008), Chaps. 3, (6,10)
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: RNA triplet codons specifying amino acids (AA) in protein. (of codon) These AA all have hydrophobic side chains These AA all have hydrophilic side chains Note:
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RNA TRIPLET CODONS FOR AMINO ACIDS IN PROTEINS “Start” Codon: AUG(Met) “Stop” Codons: UAA UAG UGA Amino Acid (if underlined, essential in diet) 1 Codon (1 tRNA): Met Trp 2 Codons (1 tRNA): Asn Asp Cys Gln Glu His Lys Phe Tyr 3 Codons (1 tRNA): Ile 4 Codons (2 tRNAs): Ala Gly Pro Thr Val 6 Codons (3 tRNAs): Arg Leu Ser
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Second base in codon -------------------------------------------------------------------------- UUY Phe UAY Tyr UGY Cys U UCN Ser UGA Stop UUR Leu UAR Stop UGG Trp -------------------------------------------------------------------------- CAY His C CUN Leu CCN Pro CGN Arg First CAR Gln base -------------------------------------------------------------------------- AUH Ile AAY Asn AGY Ser A ACN Thr AUG Met AAR Lys AGR Arg -------------------------------------------------------------------------- GAY Asp G GUN Val GCN Ala GGN Gly U C A G Table 10.5 simplified (Y = U,C; R = A,G; H = U,C,A; N = U,C,A,G)
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Fig. 10.17 Four levels of protein structure.
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