BIO 08 - 01 OCT - Outline BIO152: Mutation: effect on...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
1 9/30/2008 1 BIO152: Mutation: effect on phenotype Lecture 8 October 2 9/30/2008 2 Outline ± “Numbers game” in bacteria ± Mutation rate ± Mutations—random or induced? ± Role of mutation in evolution-impact on fitness (see Freeman 25.5) ± Also Microbial evolution in action by R. Lenski 9/30/2008 3 Help— Lab help in SE1085 Tuesday 11:00-1:00 Friday 11:00-1:00 Lecture help in SE3057 9/30/2008 4 Bacterial populations change When a population of bacteria is exposed to a toxic environment, some rare cells seem to grow much better than most of the other cells in the population. Does the toxic environment induce the right mutation to help at least some bacteria survive?
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
9/30/2008 5 the numbers game small volumes can hold huge numbers of bacteria: One milliliter (1 ml) of bacteria or about 10 drops has ~ 1,000,000,000 (10 9) bacteria. tube contains 6.5 ml of broth with bacteria: #bacteria ~= † # of humans on this entire planet! 9/30/2008 6 the "normal" mutation rate for a gene in nature is about one mutation in every million (10 6 ) to every billion (10 9 ) cell divisions Numbers game example : 1 bacterium in 100,000,000 has a mutation in a particular gene. (A mutation rate of 1/100,000,000 or 10 -8 ) 9/30/2008 7 ± Assume ~ 1 billion (1,000,000,000 or 10 9 ) 8 = 10 bacteria in each milliliter from that tube would have a mutation in that one particular gene. typical bacterium has ~ 3500 genes, each milliliter of that culture contains approximately 35,000 mutations! 9/30/2008 8 World human population is~6.5 billion. At a mutation rate of 1/100,000,000, only 65 people in the world would exhibit a mutation in a particular gene. [even though humans have more genes than
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/25/2010 for the course BIO BIO152 taught by Professor Cordon during the Fall '09 term at University of Toronto.

Page1 / 8

BIO 08 - 01 OCT - Outline BIO152: Mutation: effect on...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online