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Chap_22_2010_v2 - Chemical Aspects of Biological Systems...

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1 http://www.chem.ucsb.edu/coursepages/index. shtml Username: chem_142c and Password: chem_242c Chemical Aspects of Biological Systems Information Pathways (142C/242C) Meeting Time : TR, 12:30-1:45 PM, Phelps Hall 3515 Instructor : Prof. Luc Jaeger Contact: [email protected] Office: PSBN 4649A Office Hrs: R, 2:00-3:00 PM; by appointment TA : wade ([email protected]) PSBN 4638, Phone 5302 TA Office Hours : TR (Wade): 11:00 AM-12:00 AM and by appointment Part 1 : overview of nitrogen metabolism A. Fixation of nitrogen (by the nitrogenase complex) B. Incorporation of NH 3 / NH 4 + through glutamate and glutamine C. Glutamine synthetase: the primary regulatory point in nitrogen metabolism D.The several classes of reactions that play fundamental roles in the biosynthesis of amino acids and nucleotides (1) Transamination reactions and other rearrangements promoted by enzymes containing pyridoxal phosphate (PLP) (2) Transfer of one-carbon groups using tetrahydrofolate (H 4 folate) or S- adenosylmethionine (Ado-Met) as cofactors (3) Transfer of amino groups derived from the amide nitrogen of Gln Part 2: brief overview of amino-acid catabolism in mammals
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2 Part 2: Brief overview of amino-acid catabolism in mammals Chap.16 Chap.18 The amino groups and the carbon skeleton take separate but interconnected pathways! Aas can be a significant source of energy! This varies depending the type of organism and metabolic conditions. Because only few organisms can produce NH3 from N2, amino groups are carefully husbanded in biological systems. Chap.22 Chap.14 Pepsin cuts protein into peptides in the stomach. Trypsin and chymotrypsin cut proteins and larger peptides into smaller peptides in the small intestine. Aminopeptidase and carboxypeptidases A and B degrade peptides into amino acids in the small intestine.
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