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Chromosome_structure(2009)Science - Comprehensive Mapping...

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DOI: 10.1126/science.1181369 , 289 (2009); 326 Science et al. Erez Lieberman-Aiden, Human Genome Interactions Reveals Folding Principles of the Comprehensive Mapping of Long-Range www.sciencemag.org (this information is current as of October 8, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/326/5950/289 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/326/5950/289/DC1 can be found at: Supporting Online Material http://www.sciencemag.org/cgi/content/full/326/5950/289#otherarticles , 14 of which can be accessed for free: cites 34 articles This article http://www.sciencemag.org/cgi/collection/genetics Genetics : subject collections This article appears in the following http://www.sciencemag.org/about/permissions.dtl in whole or in part can be found at: this article permission to reproduce of this article or about obtaining reprints Information about obtaining registered trademark of AAAS. is a Science 2009 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on October 8, 2009 www.sciencemag.org Downloaded from
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Bill & Melinda Gates Foundation); the U.S. Agency for International Development (USAID); and the National Institute of Allergy and Infectious Diseases, NIH, AI33292 (D.R.B.). The contents are the responsibility of the authors and do not necessarily reflect the views of USAID or the U.S. government. The authors declare competing financial interests. Protocol G Principal Investigators: G. Miiro, J. Serwanga, A. Pozniak, D. McPhee, O. Manigart, L. Mwananyanda, E. Karita, A. Inwoley, W. Jaoko, J. DeHovitz, L. G. Bekker, P. Pitisuttithum, R. Paris, and S. Allen. Supporting Online Material www.sciencemag.org/cgi/content/full/1178746/DC1 Materials and Methods SOM Text Figs. S1 to S10 Tables S1 to S6 References 7 July 2009; accepted 26 August 2009 Published online 3 September 2009; 10.1126/science.1178746 Include this information when citing this paper. Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome Erez Lieberman-Aiden, 1,2,3,4 * Nynke L. van Berkum, 5 * Louise Williams, 1 Maxim Imakaev, 2 Tobias Ragoczy, 6,7 Agnes Telling, 6,7 Ido Amit, 1 Bryan R. Lajoie, 5 Peter J. Sabo, 8 Michael O. Dorschner, 8 Richard Sandstrom, 8 Bradley Bernstein, 1,9 M. A. Bender, 10 Mark Groudine, 6,7 Andreas Gnirke, 1 John Stamatoyannopoulos, 8 Leonid A. Mirny, 2,11 Eric S. Lander, 1,12,13 Job Dekker 5 We describe Hi-C, a method that probes the three-dimensional architecture of whole genomes by coupling proximity-based ligation with massively parallel sequencing. We constructed spatial proximity maps of the human genome with Hi-C at a resolution of 1 megabase. These maps confirm the presence of chromosome territories and the spatial proximity of small, gene-rich chromosomes.
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