Chapter 14 slides A

Chapter 14 slides A - Chapter 14: Glycolysis,...

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Unformatted text preview: Chapter 14: Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway Glycolysis Feeder pathways Fermentation Gluconeogenesis Pentose phosphate Tumor biology, vitamin B 1 , and SNPs "Beer is living proof that God loves us and wants us to be happy." - Early 1900’s saw the conversion of “vital principle” explanations for sugar conversion to CO 2 and H 2 0 to one that involved enzymes, cofactors, pathways, etc. Protein purification Vitamins Enzyme mechanisms Disease Development of drugs Glycolysis Fermentation (anaerobic glucose degradation, ancient) Three core rxns of glycolysis: glucose to pyruvate; ATP synthesis by high energy cmpds; hydride transfer to make NADH Large part of energy remains in pyruvate and is released via citric acid cycle Mg +2 dependency Induced fit mechanism driven by glucose binding, stops nonproductive cycling using water as nucleophile Ubiquitous enzyme Isozymes: liver has hexokinase IV vs other hexokinases; same rxn different genes PFK-2 makes 2,6 bisphosphate fructose in different path Committed step in glycolysis Highly regulated enzyme (PFK-1); ATP low, activity goes up; ATP high, inhibition His is essential for steps 1 and 4 Glu is essential for steps 2 and 3 Reversible aldol condensation Class I: use Schiff base intermediate; Class II: use zinc ion Payoff phase Acyl phosphate, high energy intermediate Covalent thiohemiacetal Covalent acyl-enzyme intermediate Phosphorolysis Covalent thiohemiacetal...
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This note was uploaded on 04/25/2010 for the course CHEM 142b taught by Professor Perona,j during the Spring '08 term at UCSB.

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Chapter 14 slides A - Chapter 14: Glycolysis,...

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