Chapter 15 lecture

Chapter 15 lecture - Anyone with a score less than 40 is in...

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Anyone with a score less than 40 is in jeopardy of receiving a grade of C or lower if they continued at this level
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Chapter 15: Principles of Metabolic Regulation: Glucose and Glycogen
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Glycogen and starch: concentrated and dynamic energy storage strategies (fats, proteins, glycogen: 140, 24, 1) Hepatocyte Glycogen associated with ER
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Three core enzymes for glycogen breakdown: phosphorylase, debranching enzyme, mutase
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When blood glucose needs to be replenished….from the liver to the other parts of the body (e.g., brain) Integral membrane protein found in liver/kidney only
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Irreversible entry into synthesis pathways (e.g., glycogen synthesis) Binding energy Leaving group activation Zip coding
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Follow the stereochemistry….what does this suggest for the mechanism? Glycogen synthesis
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How does the process get started???? transglycosylase
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Answer: autocatalytic glycogenin….enzyme and primer! Rossman fold; Mn +2 ; Tyr194
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Related glycosyltransferases Beta strands = triangles; circles = helices
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Active site of glycogenin showing interactions with Mn +2 and UDP- glucose
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Variables which metabolic “machinery” needs to respond to : 100 fold changes in ATP requirement O 2 availability Availability of energy sources…fat, protein, carbohydrates How to deal with this? Answer: regulation Genome commitment, evolutionary pressure Enzymes….the ultimate target of evolutionary pressure
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This note was uploaded on 04/25/2010 for the course CHEM 142b taught by Professor Perona,j during the Spring '08 term at UCSB.

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Chapter 15 lecture - Anyone with a score less than 40 is in...

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