Chapter 16 lecture

Chapter 16 lecture - Saturday 4PM 1171 Tuesday Feb. 16 ,...

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Unformatted text preview: Saturday 4PM 1171 Tuesday Feb. 16 , 4-5PM, PSBN 4606 Dr. Koby Levy, Weizmann Institute Post-Translational Modifications: Biophysics and Evolution Wednesday Feb. 24 , 11-12, MRL 2053 Dr. Celia Goulding, UC Irvine "Discovery of a unique mycobacterial heme uptake system: A structural and biochemical study" Chapter 16: The Citric Acid Cycle Only a Small Amount of Energy Available in Glucose is Captured in Glycolysis 2 G = -146 kJ/mol Glycolysis Full oxidation (+ 6 O 2 ) G = -2,840 kJ/mol 6 CO 2 + 6 H 2 O GLUCOSE Aerobic conversion of glucose to CO 2 and H 2 0 (respiration).three stages Chapter 19 Chapter 17 Chapter 18 evolutionary origin: 2.5 billion years ago used by animals, plants, and many microorganisms Occurs in mitochondria glycolysis/cytosol; stage 3/mitochondrial membrane Pyruvate Dehydrogenase Complex (PDC) PDC is a large ( M r = 7.8 10 6 Da) multienzyme complex- pyruvate dehydrogenase (E 1 )- dihydrolipoyl transacetylase (E 2 )- dihydrolipoyl dehydrogenase (E 3 ) short distance between catalytic sites allows channeling of substrates from one catalytic site to another channeling minimizes side reactions activity of the complex is subject to regulation (ATP) The three enzyme pyruvate dehydrogenase complex (PDH) multiple copies within...
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Chapter 16 lecture - Saturday 4PM 1171 Tuesday Feb. 16 ,...

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