chapter 21 ppt

chapter 21 ppt - Chapter 21: Lipid Biosynthesis Key...

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Unformatted text preview: Chapter 21: Lipid Biosynthesis Key intermediate in FA biosynthesis Irreversible rxn. Four step reaction: Figure 21-2 Condensation/reduction/elimination/reduction (similar, but effectively reverse of -oxidation) Distinctions from oxidative biosynthesis: electron carrier (NADPH, vs NAD + in oxidation) activation (ACP and enzyme cysteine vs CoA in oxidative)-SH group of ACP Cysteine of ketoacyl-ACP synthase Loss of CO 2 drives this reaction Pantothenic acid, B 5 , CoA -ketoacyl-ACP synthase = KS -ketoacyl-ACP reductase = KR -hydroxyacyl-ACP dehydratase= HD Enoyl-ACP reductase = ER Malonyl CoA ACP transferase = MT Acetyl-CoA-ACP transacetylase = AT Seven cycles gives 16 carbon saturated palmitoyl-ACP 7 ATP and 14 NADPH Evolutionary theme Vertebratedimer of 480,000 M r Nucleotides, amino acids and glucose NADPH NAD + Major energy storage routeFA and triacylglycerols Acetyl-CoA carboxylase is rate limiting step Regulatory site Feedback inhibition Plant enzyme regulated by pH and Mg +2 instead, driven by changes in photosynthetic activity Long chain FA made from palmitate extension..stearate, etc. Smooth ER and mitochondria animals Molecular oxygen dependent enzymes: Oxidase (O 2 e acceptor, no oxygen atoms in product) Oxygenase (oxygen atoms are incorporated) Dioxygenase Monooxygenase Hydroxylase MFO Cytochrome P-450 Colored ('chrome') cellular ('cyto') proteins, with a "pigment at 450 nm", Soret peak at 450 nm when the heme iron is reduced and complexed to CO.at 450 nm when the heme iron is reduced and complexed to CO....
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This note was uploaded on 04/25/2010 for the course CHEM 142b taught by Professor Perona,j during the Spring '08 term at UCSB.

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chapter 21 ppt - Chapter 21: Lipid Biosynthesis Key...

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