Wed1.29.09 lec_wk6_Mutation_chp 14 Genetics by Hartl

Wed1.29.09 lec_wk6_Mutation_chp 14 Genetics by Hartl -...

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Yilan Shi Mutations – chp 5 in Genetics by Hartl book Corresponds to Wed, Jan 29, 2009 Lect Mutation = heritage change in genes Germ line mutation= mutations in gametes – passed onto progeny Somatic mutations = not passed on, only affect parent- ex: Mosaic of cells- mix of normal and mutated cells- mosaic cat coat Conditional mutation = turned off/on by experimenter Restrictive conditions = certain, controlled conditions that are induced to simulate mutations Permissive “ “ = all conditions except restrictive. Mutations can be classified by how they change gene expression: Loss of function mutations, null mutations, knock-outs : complete gene inactivation. Function totally lost-usually recessive o Deletion of part of a gene, AA substitutions (larger substitutions than nucleotide- 3 dTP substitutns) o Amorphic mutations Hypomorphic/leaky : reduce function, not completely stop. Usually recessive o Nucleotide substitutions (smaller level than AA’s)
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This note was uploaded on 04/25/2010 for the course LIFE SCI 504675445 taught by Professor Dr.merriam during the Winter '09 term at UCLA.

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Wed1.29.09 lec_wk6_Mutation_chp 14 Genetics by Hartl -...

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