LS3-2-10 - Advantages of Drosophila Lifecycle: 12 days Easy...

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Lifecycle: 12 days Easy detection of mutant phenotypes Chromosome 2 Advantages of Drosophila
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Arabidopsis thaliana 45 days from seed to seed ~10,000 seeds per plant Plants Peas - studied by Mendel (1865) Corn - studied by McClintock (1955)
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Model >90% similarity to humans ETHICS - can manipulate genetically Shows many of same defects, responses, biochemical pathways as humans. KIT is a transmembrane tyrosine-kinase receptor - defects in KIT affect pigmentation, supply of blood cells,and production of germ cells Mouse (Mus musculus) Proteome : ~30,000 proteins 10 11 Cells
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Lecture 2 DNA as genetic material DNA Structure
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Figs. 1.2 & 1.3
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Fig. 1.2(cont.)
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Three critical experiments showed that DNA is the Genetic Material Fig. 1.2 experiment (1944) transforming principal experiment (1952) Bacteriophage T2 1. Griffith experiment (1928) Streptococcus pneumoniae
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1. Frederick Griffith, 1928 • working with two strains of Streptococcus pneumoniae: LETHAL strain contains a polysaccharide capsule making it appear SMOOTH (S) and allowing it to evade the host immune system NON-lethal strain lacks the
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This note was uploaded on 04/26/2010 for the course LS 252-009-20 taught by Professor Chen during the Spring '09 term at UCLA.

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LS3-2-10 - Advantages of Drosophila Lifecycle: 12 days Easy...

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