LS3-5-10.4

LS3-5-10.4 - Lecture 5 RNA Structure tRNA rRNA mRNA the...

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Lecture 5 RNA Structure tRNA rRNA mRNA the Genetic Code Allison: p54-61 p79-84 see Table 4.1 RNA is involved in a wide range of cellular processes RNA can serve as a scaffold e.g. SRP RNA can direct protein activity e.g. snoRNA, telomerase RNA can be catalytic e.g. RNAseP, ribozyme RNA can control gene expression e.g. miRNA, RNAi RNA can be genetic material e.g. viruses Fig 4.14 Three major RNA types in gene expression ribosomal RNA transfer RNA messenger RNA RNA contains ribose (2’-OH)… RNA DNA The 2’-OH group makes RNA unstable in alkali. Alkali can attack the phosphodiester bonds and break the RNA chain. The 2’-OH can be methylated.
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… and Uracil instead of Thymine RNA is often single stranded RNA is a single strand polynucleotide composed of 4 ribonucleotides: A, C, G, and U. Fig 4.1 U can base-pair with A to form 2 H bonds just like A base-pairs with T in DNA Fig 4.3 G:U base pair can also form in RNA GU wobble; Fig 4.3 RNA chains fold back on themselves to form a double helix Fig 4.2 Stem Like A-form DNA -2’-OH prevents formation of B-form -Major groove is deep and narrow Hairpin loop - minimum of 4 nucleotides
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LS3-5-10.4 - Lecture 5 RNA Structure tRNA rRNA mRNA the...

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