LS3-11-10 - Lecture 11 Viruses Bacteriophage Influenza...

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Unformatted text preview: Lecture 11 Viruses Bacteriophage Influenza Human Immunodeficiency Allison p48-52 Viroids Small Circular single-stranded RNA 250 – 400 nt; no protein encoded Lethal disease in Avocado & Coconut Prions Infectious Protein agents structurally modified Lethal slow diseases Mad Cow Disease Scrapie (sheep) Kuru, Creutzfeld-Jacob disease (humans) Molecules as Infectious Agents Viruses • Simplest form of organism • Obligate Intracellular Parasites - grow within the cells of another organism - HOST Specificity • Cannot replicate on their own - must subvert the translation machinery of the host cell Virion = one virus particle • GENOME = DNA or RNA • Single- or Double-stranded • Linear or Circular • CAPSID = Protein Coat Assembled from multiple copies of one or a few proteins • Lipid coat Some viral capsids are covered with a membrane or envelope. • Derived from the host cell membrane • Contains viral proteins (spikes) • Herpes virus Symmetric capsid • Influenza Virus No regular capsid The Virus Zoo • DNA vs. RNA • Double Stranded vs. Single Stranded • Circular vs. Linear • Segmented or Not • Plus Strand vs....
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This note was uploaded on 04/26/2010 for the course LS 252-009-20 taught by Professor Chen during the Spring '09 term at UCLA.

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LS3-11-10 - Lecture 11 Viruses Bacteriophage Influenza...

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