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LS3-12-10 - Retroviruses can Pick Up Host Cell Genes that...

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Retroviruses can Pick Up Host Cell Genes that Cause Cancer Insertional inactivation (and rarely activation) • Animal retroviruses can carry incorporated cellular genes (called proto-oncogenes) that normally regulate cell growth and behavior • Normal cells infected with retroviruses carrying altered proto-oncogenes (called oncogenes) are transformed into cancer cells • Many oncogenes now identified •First discovered in chicken sarcomas (P. Rous, 1908) •Retroviruses frequently cause cancers in animals
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Animal Virus Vectors are used to Express Recombinant Genes in Eukaryotic Cells Virus Vectors, e.g. Adenovirus and HIV, are being used in Gene Therapy Two types of recombinant gene expression strategies in eukaryotic cells •Transient Transfections •Stable Transfections (aka Transformation) Recombinant virus Foreign gene
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Lecture 12 DNA Replication Allison p108-119 + p137 (p120-123= eukaryotic)
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Cell Cycle DNA Replication M = mitosis G = gap S = DNA
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