Lecture 2 - Neural Conduction and Synaptic Transmission How...

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Neural Conduction and Synaptic Transmission How ions are involved in the production of electricity in the neurons How ions move across the membranes Definitions of action potentials Structure of the synapse Mechanism of drug effects Electrical Activity in Neurons Electrical potential – an electrical charge, the ability to do work, measured in volts Ion – a charged particle o Anion – a negatively charged ion (Cl - ) o Cation – a positively charged ion (K + , Na + ) Types of electrical activity in neurons o Resting potential o Graded potential o Action potential What is needed to measure electrical activity in a neuron? A large neuron - Giant axon of the North Atlantic Squid A sensitive recording device - Oscilloscope A small electrode - Microelectrodes Fig the squid axon The Resting Potential The Resting Potential o o Studied mechanisms responsible for the resting potential in squid axon o Won Nobel Prize in 1963 Distribution of Ions in Neurons Ions are charged particles Intracellular Fluid o Contains primarily K + and protein A - Extracellular Fluid o Contains primarily Na + and Cl -
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Results in a 70 mV difference between inside and outside of a neuron o Inside is negative, with respect to the outside o Sign (-) tells us about inside of cell Ionic Bases of the Resting Potential Factors contributing to even distributions of ions (charged particles) o Random motion – particles tend to move down their concentration gradient o Electrostatic pressure – like repels like, opposite attract Factors contributing to uneven distribution of ions
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Lecture 2 - Neural Conduction and Synaptic Transmission How...

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