Carb-lipid - 4/13/10 High carbohydrate diet Glucose...

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Unformatted text preview: 4/13/10 High carbohydrate diet Glucose •  Ac5vated pathways:   Liver and adipose •  Glycolysis •  Pentose phosphate •  FaAy acid synthesis Glucose-6-P Fructose Ribulose-5-P Pyruvate Fatty acids Acetyl-CoA CO2 + energy •  Glycolysis   PFK ­1 G6PDH Control mechanisms •  Pentose phosphate   •  FaAy acid synthesis 1 4/13/10 Low carbohydrate diet •  Ac5vated pathways:   Liver •  Gluconeogenesis •  β ­oxida5on •  Ketone body synthesis   Glucose Glycerol Oxaloacetate Pyruvate CAC intermediates Lactate Alanine Fatty acids Adipose •  Lipolysis Acetyl-CoA Ketone bodies Loss of pentose ­P pathway •  NADPH and glutathione •  Importance of glutathione:       Reduc5on of vit C and E Amino acid transport DNA repair Glutathione: γ ­Glu ­Cys ­Gly 2 ...
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