segment_2_overview_innate_immunity

segment_2_overview_innate_immunity - Innate Immune System:...

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Innate Immune System: The Border Patrol Barriers Physical Barriers Chemical Barriers Responses Phagocytosis Activation of proteins, called complement, which can punch holes in cell membranes, thus killing the cell. Inflammation that leads to an influx of phagocytic cells
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Innate Immune System Distinguishes self cells from foreign pathogens based on common structural features found in several different pathogens ( PAMPs=pathogen- associated molecular patterns).
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Cells of the Innate Immune System Express Pattern Recognition Receptors on their Cell Surface.
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Complement A set of proteins found in the blood stream (plasma) that form a proteolytic cascade,i.e. A protease B Bb Ba C A Bb Cb Ca
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Some of the complement fragments generated by proteolysis have affinity for lipid bilayers. The final result is a polymer of complement proteins that inserts into cell membranes and forms a pore. [membrane attack complex]
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This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

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segment_2_overview_innate_immunity - Innate Immune System:...

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