Segment_10_Innate_Pathogen_recog

Segment_10_Innate_Pathogen_recog - family Repeated leucine...

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Click to edit Master subtitle style 4/28/10 Pathogen Recognition during Innate Immunity
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4/28/10 Basic Strategy Recognition Recognizes common features of pathogens Differences between pathogens Differences between self and a foreign cell or substance Response Soluble defensive responses Cellular defensive responses
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4/28/10 Recognition of Common Pathogen Features by Soluble Defenses Lysozyme: peptidoglycan Defensins: bacterial membranes/cell walls Mannose-binding Lectin: mannose-containing carbohydrates C-reactive protein: Polysaccharides and phosphorylcholine Double stranded RNA induces interferon production.
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4/28/10 PAMPs ( pathogen- associated molecular patterns) are recognized by pattern recognition receptors.
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4/28/10 On family of pattern recognition receptors is the Toll-like receptor
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Unformatted text preview: family. Repeated leucine rich region. Toll-Interleukin Receptor domain found in both Toll-like receptors and the IL-1R. 4/28/10 There are many TLRs and different cells express a different array of these receptors. 4/28/10 The location of the expression of the Toll-like receptors relates to the type of molecule they are designed to sense. 4/28/10 1. LPS bound by CD14 1. TLR4 dimer and MD2 associate with CD14. 1. Activates intracellular signalling pathways. 4/28/10 Signal Transduction upon LPS stimulation of the TLR complex. 4/28/10 TLR4 is unique among Toll-like receptors in that it can use two separate intracellular signalling pathways. One leads to the production of TNF-a and other inflammatory cytokines. The other pathway leads to the production of Type I...
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This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

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Segment_10_Innate_Pathogen_recog - family Repeated leucine...

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