Segment_12 - cells areas of lymph Natural...

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Apoptosis http://www.classwire.com/resources/59/04/ 4.mov
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Systemic Effects of Pro-inflammatory  Cytokines
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Mannose-binding lectin initiates the lectin pathway  of complement activation when it binds to a  microbial surface. MBL proteases
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Lectin pathway to generation of a C3 convertase.
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The MBL/MASP complex is structurally similar to initiator of  class ical pathway of complement activation. C1
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A second acute  phase protein, C- reactive protein,  can bind to C1 and  initiate complement  activation.
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Viral Infections Day O:  Virus-infected  cells produce interferons. Day 1:  Lymphocyte like  cells in the blood begin  producing large amounts  of interferon Day 3:  NIPCs differentiate  into plasmacytoid dendritic  cells and congregate in T 
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Unformatted text preview: cells areas of lymph Natural Interferon-producing cells Natural Killer Cells • 5-25% of lymphocytes in blood • Migrate from blood into infected tissues in response to inflammatory cytokines • Functions: • Induces apoptosis in cells which contain intracellular pathogens • Secrete cytokines (predominantly IFN-γ ) The cytotoxic activity of NK cells is regulated by the balance of signals received through activating and inhibitory receptors. MIC-A and MIC-B are stress-induced proteins. NK cells have a lectin-like receptor that recognizes these and kills the cell. This eliminates ‘sick’ cells from the body....
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This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

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Segment_12 - cells areas of lymph Natural...

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