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segment_13chap3begin - Receptors of the Adaptive Immune...

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Chapter 3 Principles of Adaptive Immunity
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Basic Strategies of Innate and Adaptive Immune System Innate Adaptive Recognition Common motifs found on pathogens; Multiple types of receptors that are stably inherited. Unique features found on a specific pathogen. Receptors are of the same molecule type (general structure) but extremely diverse in their specificity. Response A basic response to all types of pathogens. Response is tailored to fit the characteristics of the pathogen and the nature of the threat.
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Specificity of the Adaptive Response
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Innate immune responses occur at the site of pathogen entry. Adaptive immune responses are initiated in secondary lymphoid tissues. Lymph nodes Spleen Mucosal associated lymphoid tissue (lamina propria and Peyer’s patches) Effector cells of adaptive immunity migrate from secondary lymphoid tissues to the site of infection. Also:
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Unformatted text preview: Receptors of the Adaptive Immune System Variable regions of B and T cell receptors are generated by gene rearrangement and this allows for the expression of many different versions of receptor within the B and T cell populations found in a single individual. B and T cell receptor genes contain multiple gene segments for each of the components that make up the variable region. Thus diversity is generated by the random selection of one gene segment out of many to be used in that particular receptor. Clonal Selection Clonal Expansion Occurs in the primary lymphoid organs: Bone marrow for B cells; Thymus for T cells Receptor gene rearrangement: Adaptive Immunity Humoral Immunity (Antibody) Delayed Hypersensitivity T cell-mediated cytotoxicity All pathogens; Extracellular bacteria Intracellular bacteria Viruses Cell-mediated Immunity...
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This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

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segment_13chap3begin - Receptors of the Adaptive Immune...

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