segment_14_Agrecognpresent

segment_14_Agrecognpresent - B Lymphocytes T Lymphocytes 1....

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Today, we will: Learn a little bit more about how B and T cells recognize antigen and the differences between them. Introduce the concepts of antigen processing and presentation to T cells. Introduce the two types of T helper cells. Discuss how T helper cells play a role in humoral responses and look at what goes on in the lymph node during a humoral response. Discuss how self versus non-self discrimination is established during T cell development. Introduce the ways in which the immune response can have adverse effects.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Adaptive Immunity Humoral Immunity (Antibody) Delayed Hypersensitivity T cell-mediated cytotoxicity All pathogens; Extracellular bacteria Intracellular bacteria Viruses Cell-mediated Immunity
Background image of page 2
1. Membrane-bound Ig is Ag receptor. 2. All Ab of a single B cell and its clonal progeny have the same Ag-binding specificity. 3. Plasma cells secrete Ab, but have little Ag receptor on their surface. 4. Memory cells retain Ag receptor.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Background image of page 9
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: B Lymphocytes T Lymphocytes 1. T cell receptor only recognizes peptide processed from Ag and in association with MHC protein on the surface of a cell. 2. CD4 + T cells recognize Ag with MHC class II and CD8 + T cells recognize Ag with MHC class I. 3. CD4 + T cells are usually T helper cells (T H ) and CD8 + T cells are usually cytotoxic T cells (T C ). Antigen Processing and Presentation on MHC Molecules. Cytotoxic T cells Helper T cells Antigen Processing for Presentation on MHC class I Molecules. Antigen Processing for Presentation on MHC Class II Molecules T Lymphocytes T H cells give rise to T H 1 cells that produce cytokines supporting inflammation, activation of T cells and macrophages, and responses to intracellular pathogens AND T H 2 cells that produce cytokines supporting B cell activation, antibody production, and responses to extracellular pathogens ....
View Full Document

This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

Page1 / 9

segment_14_Agrecognpresent - B Lymphocytes T Lymphocytes 1....

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online