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segment_15_Tbinter - T Helper cells reactive to the same...

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T Helper cells reactive to the same antigen bound by the B cell provide ‘help’ to drive B cell proliferation and differentiation into a plasma cell.
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Effector Mechanisms of Antibody
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There are five classes of immunoglobulin (Ig). They differ in their constant regions. IgM IgD IgG IgA IgE Serve as receptors for antigen on B cells that have yet to bind antigen (also called naïve or virgin B cells).
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Lymphoid Follicles Primary follicle : network of follicular dendritic cells and resting B cells. Ag challenge Secondary follicle : B cells concentrically surround a germinal center of proliferating activated B cells, some T H cells, follicular dendritic cells, macrophages.
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Germinal Center B cells mutate their Ab genes. Those that bind Ag best survive, others die by apoptosis. Plasma cells and memory cells are generated.
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The Immune System must be tolerant to self. Positive Selection Negative Selection
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Thymus High numbers of thymocytes in cortex; fewer in medulla.
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