segment_20 - PeterParham TheImmuneSystem ThirdEdition...

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The Immune System Third Edition Chapter 5 Antigen Recognition by T Lymphocytes Copyright © Garland Science 2009 Peter Parham
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Chapter 5: T cell Receptor Compare TCR structure with immunoglublin structure Delineate the mechanisms for diversity in the TCR. Describe the two types of TCRs Look at the TCR complex on the T cell surface.
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The T cell receptor resembles a membrane-associated Fab fragment of Ig. TCR is only found as a membrane protein (antigen receptor) and is never secreted.
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Hypervariable loops that bind antigenic peptides presented on MHC molecules
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α/β TCR Genetic Loci
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TCR-associated CD3 and zeta chains are responsible for signal transduction after antigen recognition. Co-expression of TCR and CD3 are required for membrane expression.
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γ /δ TCR Genetic Loci
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TCRs are even more diverse than Igs.
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TCR gains extra diversity from: 1. Alternative joining of D segments. 2. N-region nucleotide addition at all junctions (Ig,
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segment_20 - PeterParham TheImmuneSystem ThirdEdition...

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