Segment_21 - coreceptor binds to MHC class II MHC molecules...

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Role of MHC in Antigen  Processing and Presentation
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MHC and Immune Responses Discuss the role of MHC in antigen presentation to T cells. Describe the antigen processing pathway that leads to peptides being presented on MHC Class I. Describe the antigen processing pathway that leads to peptides being presented on MHC Class II. Examine the experimental evidence for MHC restriction of immune responses. Look at why MHC allele expression is linked to disease susceptibility.
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This will help you to: Understand why certain pathogens stimulate type I T helper cells and a delayed hypersensitivity response. Understand why other pathogens stimulate a cell-mediated cytotoxic response. Be able to predict whether a certain type of vaccine will provide the optimal protection. from a given disease.
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There are two types of coreceptors that  can be associated with the TCR/CD3  complex.
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The expression of these coreceptors correlates with a  differences in function.
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There are also two  different classes of  MHC molecules  which relate to these  differences in  function.
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The CD8 coreceptor binds to MHC class I and the CD4 
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Unformatted text preview: coreceptor binds to MHC class II. MHC molecules have a promiscuous binding specificity… several different peptides are capable of being bound by a single MHC molecule. MHCI binds peptides which are about 9 aa MHCII binds peptides that are13-25aa In length and are ‘anchored’ at their ends. in length and can extend beyond the pocket. MHC Class I http://www.classwire.com/resources/39/83/4.w mv MHC Class II http://www.classwire.com/resources/40/83/4.w mv MHC Class I and MHC Class II bind peptides in different intracellular compartments. MHC Class I molecules bind peptides from proteins found in the cytosol. MHC Class II molecules bind peptides from proteins present in endocytic vesicles. Cytosolic proteins are degraded in proteasomes and then transported into the endoplasmic reticulum where they can be bound by MHC class I molecules. Synthesis of MHC Class I and Generation of the MHC I/Peptide Complex....
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Segment_21 - coreceptor binds to MHC class II MHC molecules...

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