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segment_22 - Gener at ion of t he M H C Class I I/Pept ide...

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Generation of the MHC Class II/Peptide Complex
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Processing of Exogenous Ag Enzymes have acidic optima. Processing can be inhibited by chemicals that increase pH, such as chloroquine. Peptides generated are 13-18 amino acids long.
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The TCR interacts with both the peptide and the MHC molecules.
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The cellular distribution of MHC Class I and MHC Class II molecules differs. MHC Class I is on all nucleated cells. MHC Class II is predominantly found on professional antigen-presenting cells.
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Regulation of MHC Some cytokines (I nterferons α, β , γ and TNF) upregulate MHC class I Heightened anti- viral immunity. I nterferon- γ increases MHC class I I expression (except in B cells).
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