segment_25 - Summary MHC molecules are polymorphic. MHC...

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MHC allotypes  are concentrated in the sites that bind  peptide and the TCR.
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MHC molecules are codominantly expressed. [No allelic exclusion of MHC molecules.] Therefore,  heterozygotes  can bind a larger  array of peptides  from a given  pathogen.
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Homozygous for 2 or 3  loci Homzygous for 1 locus Heterozygous
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Exposure to Pathogens Selects for MHC Polymorphisms
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In a cross between outbred parents, there is a 1 in 4 chance that offspring * But sometimes, recombination yields new haplotypes. *
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Generation of New MHC Alleles
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Unformatted text preview: Summary MHC molecules are polymorphic. MHC molecules are codominantly expressed. Therefore, each cell expresses 6 different MHC class I molecules. Each mouse antigen presenting cell expresses 8 different MHC II molecules. [Human have one more MHC class II locus than a mouse.] The MHC alleles a person has influences what antigen epitopes they can respond to and thus are linked to disease susceptibility. MHC molecules are the major determinants of whether a transplanted organ is accepted or rejected....
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segment_25 - Summary MHC molecules are polymorphic. MHC...

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