segment_31 - made in secondary lymphoid tissue • The...

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Chapter 8 T Cell-Mediated Immunity Copyright  ©  Garland Science 2009
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Morphological  Changes in Dendritic  Cells as They Migrate  to the Draining Lymph  Node.
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Toll-like Receptor Expression and Dendritic Cell Function   Dendritic cells carry all of the TLRs except TLR9.    Signals from TLRs activate dendritic cells.    TLR stimulation leads to increased  peptide presentation  on MHC class II.   Expression of CCR7 the receptor for CCL21, which is 
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Unformatted text preview: made in secondary lymphoid tissue. • The CCR7/CCL21 mediated signal causes the dendritic cell to stop taking up and processing antigen, but rather to present peptides to the T cells. • This signal also increases MHC class I and II expression leading to long-lived peptide/MHC complexes on the surface of the mature dendritic cell. Role of Adhesion Molecules in T cell Entry into Secondary Lymphoid Tissues...
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