segment_43 - lyn is probably responsible for...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Today we will discuss:    The different subclasses of IgG and how their structural differences influence their effector functions. The role of Fc receptors in the Ab effector functions Look at a few more assays using antigen/antibody interaction
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 6
Antibody-mediated Opsonization
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fc gamma Receptors
Background image of page 8
Antibody-dependent Cell-mediated Cytotoxicity
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Mast Cells and the Fc epsilon Receptor
Background image of page 10
Eosinophils using Fc ε Rs to attack shistosome larvae.
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Fc γ IIb Signal Transduction When IgG opsonized antigen crosslinks the BCR with FcgRIIb, the ITIM in the cytoplasmic tail of the FcR is phosphorylated. The src-family kinase
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: lyn is probably responsible for phosphorylating the FCgR ITIM. ITIM lyn Fc R CD 19 Fc IIb Signal Transduction 2 The phosphorylated FcgRIIb can also bind the phosphatase, SHIP, which dephosphorylates PIP3 to PI 3,4 P2. PIP3 is required for the membrane association of btk. PI3,4P2 cannot bind to the PH domain of btk and thus btk cannot be drawn into the signaling complex. Btk is required to activate MAPK pathways after BCR crosslinking. Therefore, coligation of FcgRIIb with BCR inhibits BCR signal transduction. ITIM lyn Fc R SHIP PIP3 btk PI3,4P2 btk...
View Full Document

This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

Page1 / 14

segment_43 - lyn is probably responsible for...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online