segment3_overview_innate_II

segment3_overview_innate_II - adhesion molecule expression...

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Phagocytic Cells of the Innate Immune System Neutrophils Macrophages
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Inflammation
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Leukocyte Migration to a Site of Infection http://www.classwire.com/resources/11/84/4.wmv
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Inflammatory Response: The Hallmarks Redness due to capillary dilation Heat due to capillary dilation Swelling due to increased capillary permeability…plasma from blood leaks into the tissue Pain largely pressure pain due to the swelling
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Causes of Capillary Dilation Cytokines: proteins released by phagocytic cells after they have phagocytosed a foreign substance such as a microbe. Soluble mediators released from mast cells that have been stimulated by the products of complement activation. C3 C3a Mast cell
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The cytokines and soluble mediators also alter the
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Unformatted text preview: adhesion molecule expression of endothelial cells of the capillary, allowing an influx of phagocytic cells into the site. Macrophages make two distinct responses when they recognize bacteria. The neutrophils bind to adhesion molecules that have been induced on the endothelial cells, migrate between the endothelial cells and then following the increasing concentration of chemokines to site of bacterial invasion. The inflammatory cytokines released by macrophages leads to the influx of neutrophils. Rolling Leukocytes http://www.classwire.com/resources/70/83/ 4.wmv The innate immune system makes the same basic response to all foreign invasions. bacteria...
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This note was uploaded on 04/27/2010 for the course MMG 451 taught by Professor Brooks during the Spring '08 term at Michigan State University.

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segment3_overview_innate_II - adhesion molecule expression...

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