Lecture31 - MCB 354 Lecture 31 Oxidative Phosphorylation...

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Unformatted text preview: MCB 354 Lecture 31 Oxidative Phosphorylation Reading in Lehninger : Chapter 19 OXIDATIVE PHOSPHORYLATION LEHNINGER CHAPTER 19 PP. 690-722 OVERVIEW: REDUCED PYRIDINE NUCLEOTIDES AND SUCCINATE FROM GLYCOLYSIS / TCA CYCLE GENERATE ENERGY THROUGH ELECTRON TRANSFER COUPLED PROTON TRANSLOCATION IN THE REDUCTION OF ATMOSPHERIC DIOXYGEN TO WATER THESE WILL ACCOUNT FOR 26 / 30 ATPs GENERATED FROM GLUCOSE METABOLISM WE DO NOT COVER PHOTOPHOSPHORYLATION 31-1 THE MITOCHONDRION ENZYMES OF THE OX-PHOS CHAIN AND TCA CYCLE ARE FOUND IN THE MITOCHONDRIA 1 μ ELECTRONS -> PROTON MOTIVE FORCE -> ATP TCA OX-PHOS +- 31-2 ANOTHER PICTURE SHOWING ENZYME LOCALIZATION 31-3 THE MAJOR SOURCE OF ELECTRONS FOR OX-PHOS ARE NADH AND FADH 2 OTHER DEHYDROGENASES EXIST THAT CAN COUPLE INTO OX-PHOS 1.14 V ENERGY FROM NADH DRIVES OXYGEN REDUCTION TO WATER HOMEWORK: CALCULATE ∆ G o’ FOR THIS COUPLE 31-4 IN METABOLISM WE SAW HOW ENZYMES CONTROLLED PROTON TRANSFER EVENTS IN OX-PHOS WE ARE DEALING WITH ELECTRON TRANSFER PROCESSES COMMON PROSTHETIC GROUPS INVOLVED IN ET PROCESSES: FLAVOPROTEINS - FAD OR FMN CYTOCHROMES - IRON PORPHYRINS - HEME COPPER IONS IRON - SULFUR PROTEINS CENTRAL ELECTRON CARRIERS IN THE MEMBRANE: QUINONES 31-5 FLAVOPROTEINS TWO ELECTRON CARRIERS, CYCLE THROUGH A SEMIQUINONE STATE THERE ARE TWO COUPLED PROTONATION EVENTS THERE IS A REDOX POTENTIAL ASSOCIATED WITH EACH ET REACTION 31-6 CYTOCHROMES IRON HETEROCYLES:...
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This note was uploaded on 04/28/2010 for the course MCB MCB 251 taught by Professor Kirchner during the Spring '09 term at University of Illinois at Urbana–Champaign.

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Lecture31 - MCB 354 Lecture 31 Oxidative Phosphorylation...

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