Psych 179 Lecture wk 1-1

Psych 179 Lecture wk 1-1 - Psych 179 Lecture wk# 11...

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Psych 179 Lecture wk# 1-1 Pharmacology  Inhale drug: lung  heart brain IV drug: heart  lung   heart   brain A. Figure 5-1. (In the hand out) Absorption and distribution. Drugs entering the body by way of the gastrointestinal  tract, skin or lungs must first traverse an epithelial barrier before entering the  interstitium. Drugs given subcutaneously or intramuscularly bypass the epithelial  barrier. Drugs given by any of the routes shown must traverse the capillary wall in  order to enter the circulation.  B. Drug Elimination: Half-life: time it takes to remove 50% of drug from bloodstream o Independent of drug concentration  o Constant rate (Exam questions)  o Examples: T=0  10 mg IM morphine = 70 ng/ml in blood T=2.5 hr 35 ng/ml T=5.0 hr 17.5 ng/ml T=7.5 hr 8.75 ng/ml C. Where is it occurring in the half life? Kidney- most other drugs; 1 st  order kinetics o It’s constant rate to remove Liver- alcohol metabolism; 0 order kinetics o No half life in alcohol.
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o It’s constant amount remove Half-life – time to remove half drug from the blood; constant. D.
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This note was uploaded on 04/29/2010 for the course PSYCH PSYCH 179 taught by Professor Koob during the Fall '09 term at UCSD.

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Psych 179 Lecture wk 1-1 - Psych 179 Lecture wk# 11...

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