BIBC 100 Assignments

BIBC 100 Assignments - BIBC 100 Assignments# 1 From the...

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BIBC 100 Assignments# 1 From the News and Views article: 1. They found a potential small molecule called epigallocatechini-3-gallate (EGCG) to prevent for the amyloidogenesis happening, so that Alzheimer’s and Parkinson’s diseases can be cure. 2. Antagonist means that the small molecule (EGCG) prevents formation of amyloid fibril. 3. First reason is that the small molecules are not big enough to affect the protein interact with another protein, therefore where the energy binds would mess up all the other amino acids and angstroms space. Second reason is that most of the time the contact site is flat, therefore it doesn’t give a high chance for the small molecule to get into the contact site. 4. The monomer itself is toxic and forms structured oligomers leads to amyloid fibril formation. When EGCG binds to unfolded structure, then monomer became nontoxic and forms bunch of unstructured oligomers and stop the formation of fibril formation. From the research article:
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This note was uploaded on 04/29/2010 for the course PSYCH PSYCH 179 taught by Professor Koob during the Fall '09 term at UCSD.

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BIBC 100 Assignments - BIBC 100 Assignments# 1 From the...

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