Week 10 Mimi - BIBC 100 Structural Biochemistry Handout...

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BIBC 100 Structural Biochemistry Handout l0 (Lecture 26-27) Membrane Fusion o Requirements Mimi Nguyen [email protected] OH Fri 10:30-1 o Recognition o Surfaces must be closely opposed 4 So r.rc^f-ar or,,r be v4wt.ov ad o Local disruption of bilayers (Outtr l.fqSUtS dvrt = hrnni{turon) o Bilayers fuse o Fusionproteins !A.|.d \e 4td f,tB T^-|\,a/L/ qerrr-*ucartl-N' o,nstwrct<<l gwtc,rn \ f ytgfcf "4 b" ti$Ulr rd Co1+ + i4B {ot'laqarop.rq 1cr< (co.+u.4ratcd",o.rm) o Complementary sets of TM proteins o V-SNARE: .rttlc\4 , found on surface of synaptic vesicles o T-SNARE: -t4qFt , found on surface of target MB - o Trans-SNARE Complex . 3 T-SNARES I v-sNAREhelix . Cor[ - c,ad- Motif: 7 aarcpeat where certain aaare hydrophobic (B&T Fig.3.2) o LehnFig. 11.24 tsmv\.i'., "."R. , F \\l 11| ....f tur** sNAp26 Vd1 sraees .svv'r'|\runSSNr\UE Conag\rrc rirlnrtg .p.rf, otrutc.
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This note was uploaded on 04/29/2010 for the course PSYCH PSYCH 179 taught by Professor Koob during the Fall '09 term at UCSD.

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Week 10 Mimi - BIBC 100 Structural Biochemistry Handout...

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