New Psych Note 111308

New Psych Note 111308 - Note 10/23/08 Marijuana: A. What is...

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Note 10/23/08 Marijuana: A. What is marijuana? Weed, vigorous plant, can grow to at least 10 ft tall, it’s in the oil of the plant (highest concentration in the flowers and leaves) B. Classification: Sedative- hypnotic : effect just like alcohol and more. Psychedelic- perceptually distorting C. Active Ingredients in Marijuana Smoke 60-80 different cannabinoids in marijuana smoke Delta-9- THC- main active ingredient - (Delta-9-tetrahydrocannabinol) Delta-8- THC- 50% as active Cannabinol- not psychoactive D. Source- Plant Flowers, leaves, stems, seeds ( highest to lowest) E. Source- Preparation Flowers + Leaves 5-10% Hash 20% Hash Oil up to 50 % Female plant (Canabis spp.)- , Male Plant Sinsemilla- bleeding the drugs and concentration. F. Insert Graph
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The time course for intensity of subjective “high” after consuming various doses of THC via different routes of administration. G. Medical Uses- Accepted Dronabinol (marinol): has Delta 9-THC ingredient that in marijiuana - 10 mg/person Cancer-chemotherapy AIDS Wasting Syndrome Increases appetite Weight gain H. Pharmacokinetic- THC Metabolism occurs in liver Half-life initial ~ 30-60 hours Very lipophilic and THC its metabolites can accumulate in tissue Blood levels can be detected for 6 days Urinary metabolites can be detected for up to 6 weeks. Will be positive if 15 people dosing mj = smoking 1. I. Doses & Behavior Smoked (delivered) Oral Blood Level Euphoria (threshold) 2 mg 5 mg Perceptual (threshold) 7 mg 17mg ~9.0 ng/ml Motor Impairment 7-15 mg 17-25 mg ~25-30 ng/ml
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Perceptual Distortions (marked Comatose (n=1) 15 mg 25 mg ~50-70 ng/ml, 180 ng/ml Onset Minutes UP to 60 minutes Duration 2-3 hours 3-5 hours J. Behavior Euphoria - Initial feelings of “happiness - In a group subject subject may be talkative and find everything hilarious - Much contagiousness of laughing and joking, high pitched, giggly laughter (“if there is a reason for the laughter if quickly fades; the point of the joke is lost immediately”) - Subjective feeling of “unreality” - Various sensations of lightness and/or heaviness in the body (swimming in air) Motor Changes - Inclination to engage in motor activity increased - Paradoxically, even the simplest tasks appear to require enormous effort - Disinhibition combined with incoordination and clumsiness prevents subject from attempting many activities Marked Perceptual Changes - Time perception is slowed
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- Distortions of space with near objects appearing distant - Visual “hallucinations”- flashes of light, amorphous forms of vivid color, depth of color increased - Auditory- sounds magnified, keener appreciation of rhythm and timing - Synesthesia- transmutation of senses o Seeing sounds o Hearing color Mental Performance - Impaired judgment, impaired memory and confusion - Impaired free recall memory of material learned while intoxicated
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New Psych Note 111308 - Note 10/23/08 Marijuana: A. What is...

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