diffuse optical imaging

diffuse optical imaging - Diffuse Optical Imaging BENG 101...

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David Hall, Ph.D. Assistant Adjunct Professor Departments of Radiology and Bioengineering UCSD Diffuse Optical Imaging BENG 101
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Overview Absorption and Scattering Optical Techniques Theory Fluorescence Practical Applications
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Overview Absorption and Scattering Optical Techniques Theory Fluorescence Practical Applications
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EM Spectrum
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Why NIR ? Non-ionizing radiation Low optical attenuation by tissue
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Optical Absorption Lambert-Bouguer Law (1729) μ a = ε C Beer’s Law (1852) Combined to give Beer-Lambert Law
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Optical Absorption by Tissue
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Optical Absorption by Tissue
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Optical Absorption by Tissue
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Optical Absorption by Tissue Lipid
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Absorption Spectroscopy Given a mixture of absorbers (chromophores), absorption spectroscopy permits the concentration of each chromophore to be calculated. μ a of tissue is ~ 0.01 mm -1
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Optical Scattering
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Optical Scattering by Tissue 1000 times stronger than absorption Follows a power law with wavelength Scattering (μ s ) = A . λ -B Lord Rayleigh B = 4 (for small particles) For spherical particles of radius r - Mie theory μ s of tissue is ~ 10 mm -1
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Optical Attenuation by Tissue Attenuation is a function of both absorption and scattering. μ t = f ( μ a , μ s )
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Overview Absorption and Scattering Optical Techniques Theory Fluorescence Practical Applications
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Optical Imaging Methods Ballistic Imaging (collimated) Coherent Imaging (OCT) Polarization Imaging Limited to thin tissue samples (mm)
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Diffuse Optical imaging Continuous Wave (CW) Source (I o ) Detector (I) Limited to Low resolution (cm), Attenuation images μ t = f ( μ a , μ s )
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Diffuse Optical imaging Time Domain (TD) Pulse Source (I o ) TD Detector I = f(t) Temporal Point Spread Function (TPSF)
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Diffuse Optical imaging Time Domain (TD) S D TPSF TPSF permits Time-gating to improve attenuation spatial resolution (cm to mm)
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This note was uploaded on 04/30/2010 for the course BENG 101 taught by Professor Silva,g during the Fall '08 term at UCSD.

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diffuse optical imaging - Diffuse Optical Imaging BENG 101...

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