Unformatted text preview: 2 . What principle would you use? Please explain in detail. What applications would you foresee for such a device in medicine? 4. * Design Problem . Blood clot obstruction The vessels in the microcirculation may be obstructed by a blood clot. Such clots can arise by binding and polymerization of the plasma protein fibrinogen on a specific receptor on the surface of the endothelial cell. The yield stress (a shear stress at which the material will start to deform and move) in a blood clot is of the order of magnitude of 2000 dyn/cm 2 . - Find the pressure drop necessary to push out a blood clot from a capillary with diameter of 10 μm and length 200 μm. - How large is this pressure drop compared to the pressure drop across the entire circulation (see any text in Cardiovascular Physiology)?- What technique would you design to remove such blood clot? * The problem needs to be turned in for grading. 1...
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This note was uploaded on 04/30/2010 for the course BENG 112A taught by Professor Mcculloch during the Winter '09 term at UCSD.
- Winter '09