SP 2010_-_Fidelity of Replication

SP 2010_-_Fidelity of Replication - b conformational change...

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Fidelity of Replication 1. balance in dNTPS because a dNTP present at high levels is more likely to be misincorporated conversely, a dNTP present at low levels is likely to be replaced by a dNTP at high levels. 2. 2 stages polymerase reaction: a. dNTP selection by base pairing
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Unformatted text preview: b. conformational change induced by Watson-Cricks basepair required for polymerization activity 3. 3’ 5’ exonuclease activity of Poly I and Poly I I I act as proofreading mechanism 4. additional DNA repair mechanism with set of enzymes (Poly I I)...
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