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Unformatted text preview: glucuronic acid attaches to the drug, the drug becomes water soluble and is able to move to the colon for elimination Ionization- the process of an acid giving up a proton or a base accepting a proton converting the acid/base into a charge ion • passive diffusion in weak acids and weak bases • all drugs are either weak acids or weak bases • charge is very important if the drug needs to move through the membrane • acid drugs and ionization o example: drink one cup of orange juice, will increase the acid in the stomach. When an HA drug enters the stomach it will be in the HA more than A-o application: A weak acid drug with a pKa = 4 is dissolved in a buffer solution with a pH = 1.0. How much of the drug is ionized? o application: movement down a gradient • base drugs and ionization...
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This note was uploaded on 05/03/2010 for the course CHEM CHEM 118 taught by Professor Staff during the Spring '10 term at UCSD.
- Spring '10