Note 04 - glucuronic acid attaches to the drug, the drug...

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Continued with last Friday slide - Bioavailability - the amount of drug availability for absorption at target site - oral administration o drug passes through membrane -- first pass metabolism o not all of the drug is given back The Human System compartments where drug is absorbed: o esophagus o stomach o small intestine (duodenum) o colon o rectum o liver - nutrients pass from small intestine to liver by the portal vein -- portal of circulation it also remove compound by metabolism through the bile nutrients can move out of the liver to the small intestine elimination biliary tract - path by which bile is secreted by the liver on its way to the duodenum, or small intestine elimination of drugs X --> X-GluA o enzyme - UDP-glucuronic acid-transferase o cofactor - UDP-glucuronic acid nucleotide dugar o inhibition enzyme - β-glucuronidase glucuronic acid is very water soluble; whereas the drug is very hydrophobic. When
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Unformatted text preview: glucuronic acid attaches to the drug, the drug becomes water soluble and is able to move to the colon for elimination Ionization- the process of an acid giving up a proton or a base accepting a proton converting the acid/base into a charge ion • passive diffusion in weak acids and weak bases • all drugs are either weak acids or weak bases • charge is very important if the drug needs to move through the membrane • acid drugs and ionization o example: drink one cup of orange juice, will increase the acid in the stomach. When an HA drug enters the stomach it will be in the HA more than A-o application: A weak acid drug with a pKa = 4 is dissolved in a buffer solution with a pH = 1.0. How much of the drug is ionized? o application: movement down a gradient • base drugs and ionization...
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This note was uploaded on 05/03/2010 for the course CHEM CHEM 118 taught by Professor Staff during the Spring '10 term at UCSD.

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Note 04 - glucuronic acid attaches to the drug, the drug...

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